Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Editing autoreactive TCR enables efficient positive selection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2002

Santori Fabio R, Arsov Ivica, Lilić Mirjana, Vukmanović Stanislav, Lili Mirjana

Abstract excerpt

Allelic exclusion is inefficient at the TCRalpha locus, allowing a sizeable portion of T cells to carry two functional TCRs. The potential danger of dual TCR expression is a rescue of autoreactive TCRs during selection in the thymus and subsequent development of autoimmunity. In this study, we examine the reason(s) for replacing an autoreactive TCR and for allowing the survival of cells carrying two TCRs. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Autoimmunity
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to Gene Rearrangement, T-Lymphocyte

Share to H-2 Antigens

Share to Histocompatibility Antigens Class II

Share to RNA Editing

Source

Identifiers

PMID: 12165493
DOI: 10.4049/jimmunol.169.4.1729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Editing autoreactive TCR enables efficient positive selection.PMID 12165493Read ↗

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.Semantic proximity Read ↗

Receptor editing: genetic reprogramming of autoreactive lymphocytes.Semantic proximity Read ↗

Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice.Semantic proximity Read ↗

The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.Semantic proximity Read ↗

Regulation of autoreactive antibodiesSemantic proximity Read ↗

B cell receptor editing in tolerance and autoimmunitySemantic proximity Read ↗

Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8+ T CellsSemantic proximity Read ↗

TCR affinity and specificity requirements for human regulatory T-cell functionSemantic proximity Read ↗

T cells with two functional antigen-specific receptors.Semantic proximity Read ↗

How the T cell repertoire becomes peptide and MHC specific.Semantic proximity Read ↗

Learning to be tolerant: how T cells keep out of trouble.Semantic proximity Read ↗

Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.