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Possible contribution of 8-hydroxydeoxyguanosine to gene mutations in the kidney DNA of gpt delta rats following potassium bromate treatment.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000

Kuroda Ken, Ishii Yuji, Takasu Shinji, Kijima Aki, Matsushita Kohei, Masumura Ken-Ichi, Nohmi Takehiko, Umemura Takashi

Abstract excerpt

8-Hydroxydeoxyguanosine (8-OHdG) is well known not only as an effective biomarker of oxidative stress but also as a mutagenic DNA modification. Incorporation of dAMP at the opposite site of 8-OHdG induces G>T or A>C transversions. However, in vivo analyses of gene mutations caused by potassium bromate (KBrO3), which can induce 8-OHdG at carcinogenic target sites, showed that G>T was prominent in the small...

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PMID: 38432777
DOI: 10.1016/j.mrgentox.2024.503729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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