Article
Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.
Carcinogenesis - 1 Aug 2002
Wei Min, Wanibuchi Hideki, Morimura Keiichirou, Iwai Shuji, Yoshida Kaoru, Endo Ginji, Nakae Dai, Fukushima Shoji
Abstract excerpt
Arsenic is a well-documented human carcinogen, and contamination with this heavy metal is of global concern, presenting a major issue in environmental health. However, the mechanism by which arsenic induces cancer is unknown, in large part due to the lack of an appropriate animal model. In the present set of experiments, we focused on dimethylarsinic acid (DMA), a major metabolite of arsenic in most mammals...
Topics
- 8-Hydroxy-2'-Deoxyguanosine
- Animals
- Cacodylic Acid
- Carcinogens
- Cytoskeletal Proteins
- Deoxyguanosine
- Genes, p53
- Genes, ras
- Immunohistochemistry
- Male
- Mutation
- Rats
- Rats, Inbred F344
- Trans-Activators