Article
Effect of dietary treatment with dimethylarsinous acid (DMA(III)) on the urinary bladder epithelium of arsenic (+3 oxidation state) methyltransferase (As3mt) knockout and C57BL/6 wild type female mice.
Toxicology - 8 Mar 2013
Dodmane Puttappa R, Arnold Lora L, Pennington Karen L, Thomas David J, Cohen Samuel M
Abstract excerpt
Chronic exposure to inorganic arsenic (iAs) is carcinogenic to the human urinary bladder. It produces urothelial cytotoxicity and proliferation in rats and mice. DMA(V), a major methylated urinary metabolite of iAs, is a rat bladder carcinogen, but without effects on the mouse urothelium. DMA(III) was shown to be the likely urinary metabolite of DMA(V) inducing urothelial changes and is also postulated to be one...
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