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Article

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide.

Nature - 24 May 2001

Polacek N, Gaynor M, Yassin A, Mankin A S

Abstract excerpt

Peptide bond formation is the principal reaction of protein synthesis. It takes place in the peptidyl transferase centre of the large (50S) ribosomal subunit. In the course of the reaction, the polypeptide is transferred from peptidyl transfer RNA to the alpha-amino group of amino acyl-tRNA. The crystallographic structure of the 50S subunit showed no proteins within 18 A from the active site, revealing peptidyl...

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Identifiers

PMID: 11373685
DOI: 10.1038/35078113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide.PMID 11373685Read ↗

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451.Semantic proximity Read ↗

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The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.Semantic proximity Read ↗

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Important contribution to catalysis of peptide bond formation by a single ionizing group within the ribosome.Semantic proximity Read ↗

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