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Article

The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity.

RNA (New York, N.Y.) - 1 Jan 2006

Brunelle Julie L, Youngman Elaine M, Sharma Divya, Green Rachel

Abstract excerpt

Ribosomal variants carrying mutations in active site nucleotides are severely compromised in their ability to catalyze peptide bond formation (PT) with minimal aminoacyl tRNA substrates such as puromycin. However, catalysis of PT by these same ribosomes with intact aminoacyl tRNA substrates is uncompromised. These data suggest that these active site nucleotides play an important role in the positioning of minimal...

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Identifiers

PMID: 16373492
DOI: 10.1261/rna.2256706
PMCID: PMC1370883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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