Article
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
Cell - 18 May 2001
Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W
Abstract excerpt
beta-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps in embryogenesis. To study the role of beta-catenin in skin development, we introduced a conditional mutation of the gene in the epidermis and hair follicles using Cre/loxP technology. When beta-catenin is mutated during embryogenesis, formation of placodes that generate hair follicles is blocked. We show that...
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