Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WNT signals are required for the initiation of hair follicle development.

Developmental cell - 1 May 2002

Andl Thomas, Reddy Seshamma T, Gaddapara Trivikram, Millar Sarah E

Abstract excerpt

Hair follicle morphogenesis is initiated by a dermal signal that induces the development of placodes in the overlying epithelium. To determine whether WNT signals are required for initiation of follicular development, we ectopically expressed Dickkopf 1, a potent diffusible inhibitor of WNT action, in the skin of transgenic mice. This produced a complete failure of placode formation prior to morphological or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hair Follicle
Share to Edar Receptor
Share to Epidermal Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoid Enhancer-Binding Factor 1

Share to Mammary Glands, Animal

Share to Receptors, Tumor Necrosis Factor

Share to Skin Physiological Phenomena

Share to Tooth Abnormalities

Source

Identifiers

PMID: 12015971
DOI: 10.1016/s1534-5807(02)00167-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WNT signals are required for the initiation of hair follicle development.PMID 12015971Read ↗

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.Semantic proximity Read ↗

Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.Semantic proximity Read ↗

Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.Semantic proximity Read ↗

Regional Control of Hairless versus Hair-Bearing Skin by Dkk2Semantic proximity Read ↗

Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles.Semantic proximity Read ↗

Wnt signaling in skin organogenesisSemantic proximity Read ↗

Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair FollicleSemantic proximity Read ↗

Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development.Semantic proximity Read ↗

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4.Semantic proximity Read ↗

Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene.Semantic proximity Read ↗

Runx1 directly promotes proliferation of hair follicle stem cells and epithelial tumor formation in mouse skin.Semantic proximity Read ↗

MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.