Article
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Genes & development - 1 Mar 2006
Wu Xunwei, Quondamatteo Fabio, Lefever Tine, Czuchra Aleksandra, Meyer Hannelore, Chrostek Anna, Paus Ralf, Langbein Lutz, Brakebusch Cord
Abstract excerpt
Differentiation of skin stem cells into hair follicles (HFs) requires the inhibition of beta-catenin degradation, which is controlled by a complex containing axin and the protein kinase GSK3beta. Using conditional gene targeting in mice, we show now that the small GTPase Cdc42 is crucial for differentiation of skin progenitor cells into HF lineage and that it regulates the turnover of beta-catenin. In the absence...
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