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Article

Wounding mobilizes hair follicle stem cells to form tumors

14 Feb 2011

Abstract excerpt

A wide variety of human cancers are associated with injury. Although stem cells participate in tissue regeneration after wounding, it is unclear whether these cells also contribute to epithelial tumors. Human basal cell carcinomas (BCCs) are associated with misactivation of Hedgehog (Hh) signaling, commonly through acquisition of mutations in Smoothened (Smo). We have found that expression of an activated form of...

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PMID: 21321207
DOI: 10.1073/pnas.1013098108

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