Article
The small GTPase Rac suppresses apoptosis caused by serum deprivation in fibroblasts.
Molecular medicine (Cambridge, Mass.) - 1 May 2001
Ruggieri R, Chuang Y Y, Symons M
Abstract excerpt
BACKGROUND: The small GTPase Rac1 is a key signaling protein that mediates a number of important physiologic functions including the organization of the actin cytoskeleton, lipid metabolism, and gene transcription. Rac1 has also been implicated in oncogenic transformation. Expression of constitutively active Rac1 in Rat1 fibroblasts elicits serum- and anchorage-independent growth and causes tumorigenicity in nude...
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