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Article

Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.

Molecular and cellular biology - 1 Oct 2001

Zugasti O, Rul W, Roux P, Peyssonnaux C, Eychene A, Franke T F, Fort P, Hibner U

Abstract excerpt

Signals from the extracellular matrix are essential for the survival of many cell types. Dominant-negative mutants of two members of Rho family GTPases, Rac1 and Cdc42, mimic the loss of anchorage in primary mouse fibroblasts and are potent inducers of apoptosis. This pathway of cell death requires the activation of both the p53 tumor suppressor and the extracellular signal-regulated mitogen-activated protein...

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Identifiers

PMID: 11533257
DOI: 10.1128/MCB.21.19.6706-6717.2001
PMCID: PMC99815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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