Article
BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Skorski T, Wlodarski P, Daheron L, Salomoni P, Nieborowska-Skorska M, Majewski M, Wasik M, Calabretta B
Abstract excerpt
The phenotype of hematopoietic cells transformed by the BCR/ABL oncoprotein of the Philadelphia chromosome is characterized by growth factor-independent proliferation, reduced susceptibility to apoptosis, and altered adhesion and motility. The mechanisms underlying this phenotype are not fully understood, but there is evidence that some of the properties of BCR/ABL-expressing cells are dependent on the activation...
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