Article
BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Skorski T, Wlodarski P, Daheron L, Salomoni P, Nieborowska-Skorska M, Majewski M, Wasik M, Calabretta B
Abstract excerpt
The phenotype of hematopoietic cells transformed by the BCR/ABL oncoprotein of the Philadelphia chromosome is characterized by growth factor-independent proliferation, reduced susceptibility to apoptosis, and altered adhesion and motility. The mechanisms underlying this phenotype are not fully un...
Topics
- Animals
- Base Sequence
- Cell Division
- Cell Line, Transformed
- Cell Movement
- Cell Survival
- DNA Primers
- Fusion Proteins, bcr-abl
- GTP-Binding Proteins
- Gene Expression
- Hematopoietic Stem Cells
- Humans
- Leukemia, Experimental
- Mice
- Mice, SCID