Article
Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: Identification of factor specific requirements.
Oncogene - 19 Apr 2001
Nielsen K H, Gredsted L, Broach J R, Willumsen B M
Abstract excerpt
We have investigated the productive interaction between the four mammalian Ras proteins (H-, N-, KA- and KB-Ras) and their activators, the mammalian exchange factors mSos1, GRF1 and GRP, by using a modified Saccharomyces cerevisiae whose growth is dependent on activation of a mammalian Ras protein by its activator. All four mammalian Ras proteins were activated with similar efficiencies by the individual exchange...
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