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Article

Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1993

Nakafuku M, Nagamine M, Ohtoshi A, Tanaka K, Toh-e A, Kaziro Y

Abstract excerpt

NF1 was first identified as the gene responsible for the pathogenesis of the human genetic disorder neurofibromatosis type 1. cDNA cloning revealed that its putative protein product has a domain showing significant sequence homology with the mammalian Ras GTPase activating protein and two yeast Saccharomyces cerevisiae proteins, Ira1 and Ira2. The Ras GTPase activating protein-related domain of the NF1 gene...

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Identifiers

PMID: 8341688
DOI: 10.1073/pnas.90.14.6706
PMCID: PMC47001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.PMID 8341688Read ↗

Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.Semantic proximity Read ↗

Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles.Semantic proximity Read ↗

Hyperactive Ras as a therapeutic target in neurofibromatosis type 1Semantic proximity Read ↗

Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemiaSemantic proximity Read ↗

Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells.Semantic proximity Read ↗

Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.Semantic proximity Read ↗

Somatic mutations in the neurofibromatosis 1 gene in human tumors.Semantic proximity Read ↗

Characterization of Ras effector mutant interactions with the NF1-GAP related domain.Semantic proximity Read ↗

A protein required for nuclear-protein import, Mog1p, directly interacts with GTP-Gsp1p, the Saccharomyces cerevisiae ran homologue.Semantic proximity Read ↗

The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.Semantic proximity Read ↗

The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1.Semantic proximity Read ↗

Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function.Semantic proximity Read ↗

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