Article
Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1993
Nakafuku M, Nagamine M, Ohtoshi A, Tanaka K, Toh-e A, Kaziro Y
Abstract excerpt
NF1 was first identified as the gene responsible for the pathogenesis of the human genetic disorder neurofibromatosis type 1. cDNA cloning revealed that its putative protein product has a domain showing significant sequence homology with the mammalian Ras GTPase activating protein and two yeast S...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Cell Transformation, Neoplastic
- Fungal Proteins
- GTP Phosphohydrolases
- Genes, Neurofibromatosis 1
- Genes, Tumor Suppressor
- Genes, ras
- Heat-Shock Proteins
- Mice
- Molecular Sequence Data
- Mutation
- Neurofibromin 1
- Phenotype
- Proteins
- Saccharomyces cerevisiae
- ras Proteins