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Article

Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors.

The Journal of biological chemistry - 14 Dec 2001

Tian X, Feig L A

Abstract excerpt

Sos and Ras-GRF are two families of guanine nucleotide exchange factors that activate Ras proteins in cells. Sos proteins are ubiquitously expressed and are activated in response to cell-surface tyrosine kinase stimulation. In contrast, Ras-GRF proteins are expressed primarily in central nervous...

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PMID: 11560935
DOI: 10.1074/jbc.M107407200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11560935-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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