Article
A dominant activating mutation in the effector region of RAS abolishes IRA2 sensitivity.
Molecular and cellular biology - 1 Feb 1992
Tanaka K, Wood D R, Lin B K, Khalil M, Tamanoi F, Cannon J F
Abstract excerpt
Previously described mutations in RAS genes that cause a dominant activated phenotype affect the intrinsic biochemical properties of RAS proteins, either decreasing the intrinsic GTPase or reducing the affinity for guanine nucleotides. In this report, we describe a novel activating mutation in the RAS2 gene of Saccharomyces cerevisiae that does not alter intrinsic biochemical properties of the mutant RAS2...
Topics
- Adenylyl Cyclases
- Enzyme Activation
- Fungal Proteins
- GTP Phosphohydrolases
- GTPase-Activating Proteins
- Genes, Dominant
- Genes, ras
- Guanosine Triphosphate
- Kinetics
- Mutation
- Proto-Oncogene Proteins p21(ras)