Characterization of Ras effector mutant interactions with the NF1-GAP related domain.

Article

Characterization of Ras effector mutant interactions with the NF1-GAP related domain.

Oncogene - 1 Feb 1993

Marshall M S, Hettich L A

Abstract excerpt

The GTPase activating proteins Ras GAP and the neurofibromatosis-type 1 (NF1) gene product have been implicated as both potential mediators and regulators of the mitogenic effects of the ras proteins. In this study, the interactions of selected Ras effector mutants with the NF1-GAP related domain...

Topics

Amino Acid Sequence
Cell Transformation, Neoplastic
Enzyme Activation
GTP Phosphohydrolases
Genes, ras
Molecular Sequence Data
Mutation
Neurofibromin 1
Proteins
Proto-Oncogene Proteins p21(ras)

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.