Article
A tropomyosin-2 mutation suppresses a troponin I myopathy in Drosophila.
Molecular biology of the cell - 1 May 2001
Naimi B, Harrison A, Cummins M, Nongthomba U, Clark S, Canal I, Ferrus A, Sparrow J C
Abstract excerpt
A suppressor mutation, D53, of the held-up(2) allele of the Drosophila melanogaster Troponin I (wupA) gene is described. D53, a missense mutation, S185F, of the tropomyosin-2, Tm2, gene fully suppresses all the phenotypic effects of held-up(2), including the destructive hypercontraction of the indirect flight muscles (IFMs), a lack of jumping, the progressive myopathy of the walking muscles, and reductions in...
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