Muscle abnormalities in Drosophila melanogaster heldup mutants are caused by missing or aberrant troponin-I isoforms.

doi:10.1083/jcb.114.5.941

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Muscle abnormalities in Drosophila melanogaster heldup mutants are caused by missing or aberrant troponin-I isoforms.

The Journal of cell biology - 1 Sept 1991

Beall C J, Fyrberg E

Abstract excerpt

We have investigated the molecular bases of muscle abnormalities in four Drosophila melanogaster heldup mutants. We find that the heldup gene encodes troponin-I, one of the principal regulatory proteins associated with skeletal muscle thin filaments. heldup3, heldup4, and heldup5 mutants, all of which have grossly abnormal flight muscle myofibrils, lack mRNAs encoding one or more troponin-I isoforms. In contrast,...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Drosophila melanogaster
Gene Expression
Metamorphosis, Biological
Microscopy, Electron
Molecular Sequence Data
Muscles
Muscular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligonucleotides

Polymerase Chain Reaction

RNA, Messenger

Troponin

Troponin I

Source

Open in PubMed Open full text

Identifiers

PMID: 1908472
DOI: 10.1083/jcb.114.5.941
PMCID: PMC2289106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1908472-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Muscle abnormalities in Drosophila melanogaster heldup mutants are caused by missing or aberrant troponin-I isoforms.PMID 1908472Read ↗

Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities.Semantic proximity Read ↗

Abnormal muscle development in the heldup3 mutant of Drosophila melanogaster is caused by a splicing defect affecting selected troponin I isoforms.Semantic proximity Read ↗

A cis-regulatory mutation in troponin-I of Drosophila reveals the importance of proper stoichiometry of structural proteins during muscle assembly.Semantic proximity Read ↗

Specific myosin heavy chain mutations suppress troponin I defects in Drosophila muscles.Semantic proximity Read ↗

A tropomyosin-2 mutation suppresses a troponin I myopathy in Drosophila.Semantic proximity Read ↗

The Drosophila Z-disc Protein Z(210) Is an Adult Muscle Isoform of Zasp52, Which Is Required for Normal Myofibril Organization in Indirect Flight MusclesSemantic proximity Read ↗

Aberrant splicing of an alternative exon in the Drosophila troponin-T gene affects flight muscle development.Semantic proximity Read ↗

Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations.Semantic proximity Read ↗

Zasp52 in Drosophila melanogaster indirect flight muscles can serve as a model system to investigate the function of clinical variants causing myopathies.Semantic proximity Read ↗

Thin, a Trim32 ortholog, is essential for myofibril stability and is required for the integrity of the costamere in Drosophila.Semantic proximity Read ↗

A Candidate RNAi Screen Reveals Diverse RNA-Binding Protein Phenotypes in Drosophila Flight MuscleSemantic proximity Read ↗

In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.