Article
Functional recovery of troponin I in a Drosophila heldup mutant after a second site mutation.
Molecular biology of the cell - 1 Nov 1995
Prado A, Canal I, Barbas J A, Molloy J, Ferrús A
Abstract excerpt
To identify proteins that interact in vivo with muscle components we have used a genetic approach based on the isolation of suppressors of mutant alleles of known muscle components. We have applied this system to the case of troponin I (TnI) in Drosophila and its mutant allele heldup2 (hdp2). This mutation causes an alanine to valine substitution at position 116 after a single nucleotide change in a constitutive...
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