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Article

A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function.

Circulation research - 17 Jan 2014

Viswanathan Meera Cozhimuttam, Kaushik Gaurav, Engler Adam J, Lehman William, Cammarato Anthony

Abstract excerpt

RATIONALE: Regulation of striated muscle contraction is achieved by Ca2+ -dependent steric modulation of myosin cross-bridge cycling on actin by the thin filament troponin-tropomyosin complex. Alterations in the complex can induce contractile dysregulation and disease. For example, mutations between or near residues 112 to 136 of cardiac troponin-T, the crucial TnT1 (N-terminal domain of...

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Identifiers

PMID: 24221941
DOI: 10.1161/CIRCRESAHA.114.302028
PMCID: PMC4526186

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Source receipt: pubmed, retrieved 7 Sept 2026.

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