Article
A genetic approach to detect muscle protein interactions in vivo.
Trends in cardiovascular medicine - 1 Oct 2000
Ferrús A, Acebes A, Marín M C, Hernández-Hernández A
Abstract excerpt
An organism is required to identify biologically relevant protein interactions. We propose Drosophila and its indirect flight muscles as a suitable experimental system for genetic screenings for muscle protein interactions. The first attempt focused on troponin I (TnI) in view of the key role in thin filament regulation that this protein performs. Suppressors of a defined Tn I allele have been isolated as...
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