Article
Abnormal muscle development in the heldup3 mutant of Drosophila melanogaster is caused by a splicing defect affecting selected troponin I isoforms.
Molecular and cellular biology - 1 Mar 1993
Barbas J A, Galceran J, Torroja L, Prado A, Ferrús A
Abstract excerpt
The troponin I (TnI) gene of Drosophila melanogaster encodes a family of 10 isoforms resulting from the differential splicing of 13 exons. Four of these exons (6a1, 6a2, 6b1, and 6b2) are mutually exclusive and very similar in sequence. TnI isoforms show qualitative specificity whereby each muscl...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA
- Drosophila melanogaster
- Exons
- Gene Expression Regulation
- Genetic Variation
- In Situ Hybridization
- Molecular Sequence Data
- Multigene Family
- Muscle Development
- Mutation
- Phenotype
- Polymerase Chain Reaction
- RNA
- RNA Splicing
- Sequence Homology, Amino Acid