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Article

Abnormal muscle development in the heldup3 mutant of Drosophila melanogaster is caused by a splicing defect affecting selected troponin I isoforms.

Molecular and cellular biology - 1 Mar 1993

Barbas J A, Galceran J, Torroja L, Prado A, Ferrús A

Abstract excerpt

The troponin I (TnI) gene of Drosophila melanogaster encodes a family of 10 isoforms resulting from the differential splicing of 13 exons. Four of these exons (6a1, 6a2, 6b1, and 6b2) are mutually exclusive and very similar in sequence. TnI isoforms show qualitative specificity whereby each muscle expresses a selected repertoire of them. In addition, TnI isoforms show quantitative specificity whereby each muscle...

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Identifiers

PMID: 7680094
DOI: 10.1128/mcb.13.3.1433-1439.1993
PMCID: PMC359453

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