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Article

Aberrant splicing of an alternative exon in the Drosophila troponin-T gene affects flight muscle development.

Genetics - 1 Sept 2007

Nongthomba Upendra, Ansari Maqsood, Thimmaiya Divesh, Stark Meg, Sparrow John

Abstract excerpt

During myofibrillogenesis, many muscle structural proteins assemble to form the highly ordered contractile sarcomere. Mutations in these proteins can lead to dysfunctional muscle and various myopathies. We have analyzed the Drosophila melanogaster troponin T (TnT) up1 mutant that specifically affects the indirect flight muscles (IFM) to explore troponin function during myofibrillogenesis. The up1 muscles lack...

Topics

Alternative Splicing
Animals
Drosophila Proteins
Drosophila melanogaster
Exons
Larva
Muscle Contraction
Muscle Development
Mutation
Myosins
Sarcomeres

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Troponin T

Wings, Animal

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Identifiers

PMID: 17603127
DOI: 10.1534/genetics.106.056812
PMCID: PMC2013690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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