Article
Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.
The Journal of infectious diseases - 1 Jun 2001
Nomura T, Carlton J M, Baird J K, del Portillo H A, Fryauff D J, Rathore D, Fidock D A, Su X, Collins W E, McCutchan T F, Wootton J C, Wellems T E
Abstract excerpt
Chloroquine (CQ)-resistant Plasmodium vivax malaria was first reported 12 years ago, nearly 30 years after the recognition of CQ-resistant P. falciparum. Loss of CQ efficacy now poses a severe problem for the prevention and treatment of both diseases. Mutations in a digestive vacuole protein encoded by a 13-exon gene, pfcrt, were shown recently to have a central role in the CQ resistance (CQR) of P. falciparum....
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