Association of cg2 and pfmdr1 genotype with chloroquine resistance in field samples of Plasmodium falciparum from Nigeria.

doi:10.1017/s0031182099004862

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Article

Association of cg2 and pfmdr1 genotype with chloroquine resistance in field samples of Plasmodium falciparum from Nigeria.

Parasitology - 1 Oct 1999

Adagu I S, Warhurst D C

Abstract excerpt

This study examines polymorphisms in 2 genes (pfmdr1 and cg2), which have been associated with resistance to chloroquine in Plasmodium falciparum, to determine their value as predictors of resistance status. Among field samples from children in Zaria, northern Nigeria, the Tyr-86 polymorphism in pfmdr1 and Ala-281 and the Dd2 kappa repeat of cg2, were significantly associated. In 8 samples classified resistant by...

Topics

ATP-Binding Cassette Transporters
Animals
Child
Child, Preschool
Chloroquine
Drug Resistance
Genes, Protozoan
Genotype
Humans
Infant
Malaria, Falciparum
Nigeria
Plasmodium falciparum
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Protozoan Proteins

Source

Open in PubMed

Identifiers

PMID: 10581611
DOI: 10.1017/s0031182099004862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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