Article
Carrier rate of APC I1307K is not increased in inflammatory bowel disease patients of Ashkenazi Jewish origin.
Human genetics - 1 Mar 2001
Silverberg M S, Clelland C, Murphy J E, Steinhart A H, McLeod R S, Greenberg G R, Cohen Z, Siminovitch K A
Abstract excerpt
Colorectal cancer (CRC) occurs with an increased incidence in individuals with chronic inflammatory bowel disease (IBD) of the colon. Recent data suggest that a family history of colorectal cancer is an independent risk factor for CRC in IBD, an observation that implies that genetic factors are relevant to the development of CRC in this context. Among the genetic defects associated with CRC, the APC I1307K...
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