Article
The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer.
Cancer research - 15 Jul 1998
Lothe R A, Hektoen M, Johnsen H, Meling G I, Andersen T I, Rognum T O, Lindblom A, Børresen-Dale A L
Abstract excerpt
Recently, a T-to-A transversion creating an 8-base mononucleotide tract in the APC gene, resulting in substitution of lysine for isoleucine at codon 1307 (I1307K), was found in a subset of Ashkenazi Jews. This sequence variant was most frequent in colorectal cancer patients with a positive family history of colorectal cancer. To determine whether the I1307K variant plays a role in colorectal or breast cancer...
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