The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer.

Article

The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer.

Cancer research - 15 Jul 1998

Lothe R A, Hektoen M, Johnsen H, Meling G I, Andersen T I, Rognum T O, Lindblom A, Børresen-Dale A L

Abstract excerpt

Recently, a T-to-A transversion creating an 8-base mononucleotide tract in the APC gene, resulting in substitution of lysine for isoleucine at codon 1307 (I1307K), was found in a subset of Ashkenazi Jews. This sequence variant was most frequent in colorectal cancer patients with a positive family...

Topics

Alleles
Breast Neoplasms
Colorectal Neoplasms
Female
Genes, APC
Humans
Male
Norway

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