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Article

Elucidation of the minimal sequence required to imprint H19 transgenes.

Genomics - 1 Apr 2001

Cranston M J, Spinka T L, Elson D A, Bartolomei M S

Abstract excerpt

The imprinted mouse H19 gene exhibits maternal allele-specific expression and paternal allele-specific hypermethylation. We previously demonstrated that a 14-kb H19 minitransgene possessing 5' differentially methylated sequence recapitulates the endogenous H19 imprinting pattern when present as high-copy arrays. To investigate the minimal sequences that are sufficient for H19 transgene imprinting, we have tested...

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Share to DNA Methylation
Share to Enhancer Elements, Genetic
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Imprinting

Share to Recombination, Genetic

Share to RNA, Long Noncoding

Share to RNA, Untranslated

Share to Transgenes

Source

Identifiers

PMID: 11352570
DOI: 10.1006/geno.2001.6514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Elucidation of the minimal sequence required to imprint H19 transgenes.PMID 11352570Read ↗

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Deletion of a silencer element disruptsH19imprinting independently of a DNA methylation epigenetic switchSemantic proximity Read ↗

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