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Article

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.

Genes & development - 1 Dec 1998

Thorvaldsen J L, Duran K L, Bartolomei M S

Abstract excerpt

Differentially methylated sequences associated with imprinted genes are proposed to control genomic imprinting. A 2-kb region located 5' to the imprinted mouse H19 gene is hypermethylated on the inactive paternal allele throughout development. To determine whether this differentially methylated domain (DMD) is required for imprinted expression at the endogenous locus, we have generated mice harboring a 1.6-kb...

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Identifiers

PMID: 9851976
DOI: 10.1101/gad.12.23.3693
PMCID: PMC317260

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.PMID 9851976Read ↗

Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.Semantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

Imprinted expression and methylation of the mouse H19 gene are conserved in extraembryonic lineages.Semantic proximity Read ↗

Establishment and maintenance of H19 imprinting in the germline and preimplantation embryo.Semantic proximity Read ↗

A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development.Semantic proximity Read ↗

Role for DNA methylation in genomic imprinting.Semantic proximity Read ↗

Maintenance of Paternal Methylation and Repression of the Imprinted H19 Gene Requires MBD3Semantic proximity Read ↗

Regulatory mechanisms at the mouse Igf2/H19 locus.Semantic proximity Read ↗

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