Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.

doi:10.1101/gad.12.23.3693

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Article

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.

Genes & development - 1 Dec 1998

Thorvaldsen J L, Duran K L, Bartolomei M S

Abstract excerpt

Differentially methylated sequences associated with imprinted genes are proposed to control genomic imprinting. A 2-kb region located 5' to the imprinted mouse H19 gene is hypermethylated on the inactive paternal allele throughout development. To determine whether this differentially methylated d...

Topics

Alleles
Animals
DNA Methylation
Female
Genomic Imprinting
Heterozygote
Homozygote
Insulin-Like Growth Factor II
Male
Mice
Models, Genetic
Muscle Proteins
RNA, Long Noncoding
RNA, Untranslated
Sequence Deletion
Sex Factors

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