Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Randomly Integrated Transgenic <i>H19</i> Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ Cells

23 Jun 2009

Abstract excerpt

The imprinted expression of the mouse Igf2/H19 locus is governed by the differential methylation of the imprinting control region (ICR), which is established initially in germ cells and subsequently maintained in somatic cells, depending on its parental origin. By grafting a 2.9-kbp H19 ICR fragment into a human beta-globin yeast artificial chromosome in transgenic mice, we previously showed that the ICR could...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19546235
DOI: 10.1128/mcb.00275-09

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Randomly Integrated Transgenic <i>H19</i> Imprinting Control Region Acquires Methylation Imprinting Independently of Its Establishment in Germ CellsPMID 19546235Read ↗

<i>H19</i> Imprinting Control Region Methylation Requires an Imprinted Environment Only in the Male Germ LineSemantic proximity Read ↗

Genomic imprinting recapitulated in the human β-globin locusSemantic proximity Read ↗

The H19 Imprinting Control Region Mediates Preimplantation Imprinted Methylation of Nearby Sequences in Yeast Artificial Chromosome Transgenic MiceSemantic proximity Read ↗

CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR.Semantic proximity Read ↗

The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization periodSemantic proximity Read ↗

Transient establishment of imprinted DNA methylation of transgenic human IC1 sequence in mouse during the preimplantation period.Semantic proximity Read ↗

Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic miceSemantic proximity Read ↗

TheH19Differentially Methylated Region Marks the Parental Origin of a Heterologous Locus without Gametic DNA MethylationSemantic proximity Read ↗

Fate of methylated/unmethylated H19 imprinting control region after paternal and maternal pronuclear injection.Semantic proximity Read ↗

Elucidation of the minimal sequence required to imprint H19 transgenes.Semantic proximity Read ↗

CpG methylation regulates the Igf2/H19 insulator.Semantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.