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Article

Mitochondrial DNA in human malignancy.

Mutation research - 1 May 2001

Penta J S, Johnson F M, Wachsman J T, Copeland W C

Abstract excerpt

Alterations in expression of mitochondrial DNA (mtDNA)-encoded polypeptides required for oxidative phosphorylation and cellular ATP generation may be a general characteristic of cancer cells. Mitochondrial DNA has been proposed to be involved in carcinogenesis because of high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. Since mtDNA lacks introns, it has been suggested...

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Identifiers

PMID: 11344040
DOI: 10.1016/s1383-5742(01)00053-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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