Article
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis.
Neuron - 20 Sept 2012
Matta Samer, Van Kolen Kristof, da Cunha Raquel, van den Bogaart Geert, Mandemakers Wim, Miskiewicz Katarzyna, De Bock Pieter-Jan, Morais Vanessa A, Vilain Sven, Haddad Dominik, Delbroek Lore, Swerts Jef, Chávez-Gutiérrez Lucía, Esposito Giovanni, Daneels Guy, Karran Eric, Holt Matthew, Gevaert Kris, Moechars Diederik W, De Strooper Bart, Verstreken Patrik
Abstract excerpt
LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2(G2019S) gain-of-kinase function, we show that LRRK2 affects synaptic endocytosis by phosphorylating EndoA at S75, a residue in the BAR...
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