Article
Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum.
Current opinion in microbiology - 1 Aug 2001
Carlton J M, Fidock D A, Djimdé A, Plowe C V, Wellems T E
Abstract excerpt
Chloroquine resistance in Plasmodium falciparum has recently been shown to result from mutations in the novel vacuolar transporter, PfCRT. Field studies have demonstrated the importance of these mutations in clinical resistance. Although a pfcrt ortholog has been identified in Plasmodiumvivax, th...
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