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Article

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.

Nature - 17 May 1990

Foote S J, Kyle D E, Martin R K, Oduola A M, Forsyth K, Kemp D J, Cowman A F

Abstract excerpt

The lethal form of human malaria caused by Plasmodium falciparum is virtually uncontrollable in many areas because of the development of drug resistance, in particular chloroquine resistance (CQR). CQR is biologically similar to the multiple drug resistance phenotype (MDR) of mammalian tumour cells, as both involve expulsion of drug from the cell and both can be reversed by calcium channel antagonists. A...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Chloroquine
Drug Resistance
Genes
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Polymerase Chain Reaction

Polymorphism, Genetic

Source

Identifiers

PMID: 2185424
DOI: 10.1038/345255a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2185424-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.PMID 2185424Read ↗

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