Article
Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2001
Sekine H, Reilly C M, Molano I D, Garnier G, Circolo A, Ruiz P, Holers V M, Boackle S A, Gilkeson G S
Abstract excerpt
Complement activation and tissue deposition of complement fragments occur during disease progression in lupus nephritis. Genetic deficiency of some complement components (e.g., Factor B) and infusion of complement inhibitors (e.g., Crry, anti-C5 Ab) protect against inflammatory renal disease. Paradoxically, genetic deficiencies of early components of the classical complement pathway (e.g., C1q, C4, and C2) are...
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