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Article

C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse.

Molecular immunology - 1 Apr 2009

Wenderfer Scott E, Wang Hongyu, Ke Baozhen, Wetsel Rick A, Braun Michael C

Abstract excerpt

The development and progression of systemic lupus erythematosus (SLE) is strongly associated with complement activation and deposition. The anaphylatoxin C3a is a product of complement activation with immunomodulatory properties, and the receptor for C3a (C3aR) is not only expressed by granulocytes and antigen presenting cell populations, but it is also strongly up-regulated in lupus prone mice with active...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19167760
DOI: 10.1016/j.molimm.2008.12.004
PMCID: PMC2697606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse.PMID 19167760Read ↗

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