Article
Modulation of renal disease in MRL/lpr mice genetically deficient in the alternative complement pathway factor B.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2000
Watanabe H, Garnier G, Circolo A, Wetsel R A, Ruiz P, Holers V M, Boackle S A, Colten H R, Gilkeson G S
Abstract excerpt
In systemic lupus erythematosus, the renal deposition of complement-containing immune complexes initiates an inflammatory cascade resulting in glomerulonephritis. Activation of the classical complement pathway with deposition of C3 is pathogenic in lupus nephritis. Although the alternative complement pathway is activated in lupus nephritis, its role in disease pathogenesis is unknown. To determine the role of the...
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