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Article

Membrane protein Crry maintains homeostasis of the complement system.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2008

Wu Xiaobo, Spitzer Dirk, Mao Dailing, Peng Stanford L, Molina Hector, Atkinson John P

Abstract excerpt

Complement activation is tightly regulated to avoid excessive inflammatory and immune responses. Crry(-/-) is an embryonic lethal phenotype secondary to the maternal complement alternative pathway (AP) attacking a placenta deficient in this inhibitor. In this study, we demonstrate that Crry(-/-) mice could be rescued on a partial as well as on a complete factor B (fB)- or C3-deficient maternal background. The C3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18684964
DOI: 10.4049/jimmunol.181.4.2732
PMCID: PMC2580744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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