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Article

Complement C4 Is Protective for Lupus Disease Independent of C3

1 Feb 2002

Abstract excerpt

The role of complement C3 in mediating systemic lupus erythematosus (SLE) was examined using a double-knockout C3(null)C4(null) Fas (CD95)-deficient mouse model. Results from this study reveal significant lymphadenopathy, splenomegaly, elevated titers of anti-nuclear Abs and anti-dsDNA Abs, an increased number of anti-dsDNA-producing cells in ELISPOT assay, as well as severe glomerulonephritis in the...

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PMID: 11801636
DOI: 10.4049/jimmunol.168.3.1036

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