Article
Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms.
Circulation - 8 May 2001
Jones K G, Brull D J, Brown L C, Sian M, Greenhalgh R M, Humphries S E, Powell J T
Abstract excerpt
BACKGROUND: Abdominal aortic aneurysm is a multifactorial disorder in which inflammation is an important pathophysiological feature. In explant culture, aneurysm biopsies secrete large amounts of interleukin-6 (IL-6), and among aneurysm patients, the circulating concentration of IL-6 appears to be increased. METHODS AND RESULTS: We investigated, in 19 patients, whether aneurysm wall was an important source of...
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