Article
The interleukin-10-1082 'A' allele and abdominal aortic aneurysms.
Journal of vascular surgery - 1 Oct 2007
Bown Matthew J, Lloyd Geraint M, Sandford Rebecca M, Thompson John R, London Nicholas J M, Samani Nilesh J, Sayers Robert D
Abstract excerpt
BACKGROUND: Abdominal aortic aneurysms (AAA) are caused by inflammatory processes in the wall of the aorta resulting in degradation of structural proteins. This inflammatory process is mediated, in part, by cytokines, and interleukin-10 (IL-10) is a predominantly anti-inflammatory cytokine. A single nucleotide polymorphism in the promoter region of the IL-10 gene that affects transcription has been associated...
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