Article
The role of cytokine gene polymorphisms in the pathogenesis of abdominal aortic aneurysms: a case-control study.
Journal of vascular surgery - 1 May 2003
Bown M J, Burton P R, Horsburgh T, Nicholson M L, Bell P R F, Sayers R D
Abstract excerpt
BACKGROUND: Cytokines are the primary mediators of inflammation and also influence matrix metalloproteinase expression, both of which are important in development of abdominal aortic aneurysm (AAA). A significant, but as yet unknown, familial factor contributes to the pathogenesis of AAA. Many cytokine genes contain polymorphic sites, some of which affect cytokine production in vitro. Cytokine gene polymorphisms...
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