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Article

Localization of Aggregatibacter actinomycetemcomitans cytolethal distending toxin subunits during intoxication of live cells.

Infection and immunity - 1 Aug 2012

Damek-Poprawa Monika, Jang Jae Yeon, Volgina Alla, Korostoff Jonathan, DiRienzo Joseph M

Abstract excerpt

The cytolethal distending toxin (Cdt), produced by some clinically important Gram-negative bacterial species, is related to the family of AB-type toxins. Three heterologous proteins (CdtA, CdtB, and CdtC) and a genotoxin mode of action distinguish the Cdt from others in this toxin class. Crystal structures of several species-specific Cdts have provided a basis for predicting subunit interactions and functions. In...

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Identifiers

PMID: 22645284
DOI: 10.1128/IAI.00385-12
PMCID: PMC3434584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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