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Article

The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesis.

Toxicology letters - 31 Mar 2001

van Steeg H

Abstract excerpt

Xpa mice, which have a completely defective nucleotide excision repair (NER) pathway, have a cancer predisposition when exposed to several carcinogens. NER is one of the major DNA repair pathways in the mammalian cell, and is involved in the removal of a wide variety of DNA lesions, such as those induced by UV light, bulky adducts and DNA crosslinks. To study the role of NER in both mutagenesis and...

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PMID: 11323179
DOI: 10.1016/s0378-4274(01)00297-1

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