Article
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.
Nature - 14 Sept 1995
de Vries A, van Oostrom C T, Hofhuis F M, Dortant P M, Berg R J, de Gruijl F R, Wester P W, van Kreijl C F, Capel P J, van Steeg H, Verbeek S J
Abstract excerpt
Xeroderma pigmentosum patients with a defect in the nucleotide-excision repair gene XPA are characterized by, for example, a > 1,000-fold higher risk of developing sunlight-induced skin cancer. Nucleotide-excision repair (NER) is involved in the removal of a wide spectrum of DNA lesions. The XPA...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Cells, Cultured
- DNA Repair
- DNA-Binding Proteins
- Eye Neoplasms
- Gene Deletion
- Gene Targeting
- Genetic Predisposition to Disease
- Humans
- Mice
- Mice, Inbred C57BL
- Neoplasms, Radiation-Induced
- Radiation Tolerance