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Article

p53 haploinsufficiency profoundly accelerates the onset of tongue tumors in mice lacking the xeroderma pigmentosum group A gene.

The American journal of pathology - 1 Nov 2003

Ide Fumio, Kitada Munenori, Sakashita Hideaki, Kusama Kaoru, Tanaka Kiyoji, Ishikawa Takatoshi

Abstract excerpt

Mice lacking the xeroderma pigmentosum group A gene (XPA-/- mice), which have a complete deficiency in nucleotide excision repair (NER), are highly predisposed to tongue squamous cell carcinoma (SCC) when exposed to 4-nitroquinoline 1-oxide (4NQO). To explore the effects of the interaction of the NER machinery with p53 in oral tumorigenesis, we generated an XPA-/- mouse strain carrying mutant alleles for p53....

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Source

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Identifiers

PMID: 14578172
DOI: 10.1016/S0002-9440(10)63531-6
PMCID: PMC1892426

Genes

XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p53 haploinsufficiency profoundly accelerates the onset of tongue tumors in mice lacking the xeroderma pigmentosum group A gene.PMID 14578172Read ↗

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