Article
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Cancer research - 1 Aug 2004
Hoogervorst Esther M, van Oostrom Conny Th M, Beems Rudolf B, van Benthem Jan, Gielis Siska, Vermeulen Jolanda P, Wester Piet W, Vos Joseph G, de Vries Annemieke, van Steeg Harry
Abstract excerpt
Both nucleotide excision repair (NER) and the p53 tumor suppressor protein play crucial roles in the prevention of cells becoming cancerous. This is clearly demonstrated by the fact that NER-deficient xeroderma pigmentosum patients and Li-Fraumeni patients who carry a germ-line p53 mutation are highly tumor prone. The NER-deficient Xpa and the p53(+/-) mouse models clearly mimic their human counterparts, because...
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