Article
Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice.
Environmental and molecular mutagenesis - 1 Jan 1999
van Oostrom C T, Boeve M, van Den Berg J, de Vries A, Dollé M E, Beems R B, van Kreijl C F, Vijg J, van Steeg H
Abstract excerpt
XPA-deficient mice have a complete deficiency in nucleotide excision repair, and as such they display a cancer predisposition after exposure to several carcinogens. Besides being sensitive to genotoxic agents applied to the skin, they are also susceptible to human carcinogens given orally, like benzo[a]pyrene (B[a]P). To study the role of the tumor suppressor gene p53 in DNA repair, gene mutation, and tumor...
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